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2001. Collagen-hydroxyapatite films: piezoelectric properties. Materials Science and Engineering B-Solid State Materials for Advanced Technology 86(3):210-218. Tashjian, A. , Voelkel, E. , Singers, F. , Roberts, A. , Winklerii, M. E. and Levine, L. 1985. alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Sci 82:4535-4538. Wahl, D. A. and Czernuszka, J. T. 2006. Collagen-hydroxyapatite composites for hard tissue repair.

2006). 3 Natural polymers Natural polymers offer a number of significant advantages over synthetically-derived polymers due to their biocompatible, biodegradable and bioactive nature. By using materials that form the basic building blocks of organic systems, host response due to immunocompatibility issues can be drastically, and sometimes completely, reduced. This approach also ensures that these materials are easily biodegradable via the body’s own metabolic processes and that the resulting degradation by-products are non-toxic and can be easily assimilated or expelled from the tissue.

And Messersmith, P. B. 2003. Thermal assembly of a biomimetic mineral/collagen composite. Biomaterials 24(26):4881-4890. , Hofinger, I. and Knepper-Nicolai, B. 2001. Functionally graded collagen-hydroxyapatite materials for bone replacement. Functionally Graded Materials 2000 114:65-72. Rhee, S. H. and Tanaka, J. 1998. Hydroxyapatite coating on a collagen membrane by a biomimetic method. Journal of the American Ceramic Society 81(11):3029-3031. , Nizard, R. , Kerboull, L. and Witvoet, J. 1994. Alumina-Alumina Hip Replacement in Patients Younger Than 50 Years Old.

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